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18:T5d0,<h3>Mechanism of Action</h3><p>Mavacamten is an allosteric and reversible inhibitor selective for cardiac myosin. Mavacamten modulates the number of myosin heads that can enter “on actin” (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. Mavacamten shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with Mavacamten reduces dynamic LVOT obstruction and improves cardiac filling pressures.</p><h3>Dr. Reddy's API Offering*:</h3><ul><li>Potential NCE-1 filing opportunity.</li><li><strong>Crystalline Form A (Validated).</strong></li><li><strong>USDMF filed&nbsp;</strong>and DMF's planned for all other major markets</li><li>Planning adequate capacity with a&nbsp;<strong>short lead time of 90 days.</strong></li><li>Regulatory compliance and quality ensure&nbsp;<strong>our API is genotoxic and nitrosamine-free,</strong>&nbsp;adhering to ICH M7 guidelines.</li><li>Reliable suppliers for KSMs to ensure timely deliveries and strict adherence to specifications.</li></ul><p>To learn more about our API offerings, please read the tech sheet on <a href="https://drl-api.projectmgi.in/white-paper/white-paper-details#"><strong>Mavacamten API</strong></a> by filling out the contact form below.</p>7:["$","main",null,{"children":[["$","$L15",null,{"frontBanner":{"nid":"99","page_type_name":"Mavacamten","banner_heading":"Product Alert – Mavacamten","banner_negvigation":"White Paper > Product Alert – Mavacamten","banner_image":"https://admin.projectmgi.in/sites/default/files/2025-05/blog-details-banner_2.jpg","banner_download_brochure_link":"#","cas_no":"1642288-47-8"}}],["$","$L16",null,{}],["$","$L17",null,{"WhitePaperDetailsContent":{"nid":"96","page_type_name":"Mavacamten","description":"$18","main_heading":"Product Alert – Mavacamten","content_image":"https://admin.projectmgi.in/sites/default/files/2025-05/molicul_0.png","other_link":"https://api.drreddys.com/white-paper","phone_number":"+91 40 49002222","email":"api@drreddys.com"}}],["$","$L19",null,{"aboutDisclam":{"nid":"24","disclaimer_text":"<p>No information in this catalog - including any reference to any product or service - constitutes an offer for sale, or be construed as representing an offer for sale. Products protected under valid patents are not offered or supplied for commercial use. However, the research quantities of such products may be offered for the purpose of regulatory submissions, wherever such regulatory exemptions exist. The buyers should make their independent evaluation of the patent scenario for their respective markets and will be responsible for all patent related liabilities. Products protected under valid patents in India are not available for commercial use but would be available for Section 107A purposes.</p>"}}]]}]
